Wim van den Brink Selected Research

nalmefene (Revex)

12/2016	Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy.
4/2015	Safety and tolerability of as-needed nalmefene in the treatment of alcohol dependence: results from the Phase III clinical programme.
8/2014	Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: A 1-year, randomised controlled study.
11/2013	A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence.
4/2013	Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene.

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Wim van den Brink Research Topics

Disease

30	Alcoholism (Alcohol Abuse) 12/2021 - 08/2004
26	Substance-Related Disorders (Drug Abuse) 01/2021 - 08/2004
17	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2022 - 01/2013
13	Cocaine-Related Disorders (Cocaine Addiction) 01/2021 - 12/2003
13	Opioid-Related Disorders (Opiate Addiction) 01/2021 - 09/2002
10	Schizophrenia (Dementia Praecox) 01/2018 - 04/2008
7	Tobacco Use Disorder (Nicotine Dependence) 01/2022 - 09/2009
7	Psychotic Disorders (Schizoaffective Disorder) 04/2020 - 04/2008
5	Coma (Comas) 01/2020 - 01/2018
5	Mania (Manias) 02/2016 - 12/2007
5	Borderline Personality Disorder (Personality Disorders, Borderline) 02/2014 - 12/2002
4	Mental Disorders (Mental Disorder) 06/2022 - 09/2012
4	Heroin Dependence (Heroin Abuse) 01/2020 - 11/2003
4	Anhedonia 01/2019 - 04/2008
4	Body Weight (Weight, Body) 03/2015 - 01/2006
3	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 12/2021 - 12/2002
3	Opiate Overdose 01/2021 - 10/2017
3	Pain (Aches) 10/2019 - 01/2015
3	Personality Disorders (Personality Disorder) 11/2014 - 12/2002
3	Obesity 09/2014 - 04/2012
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2021 - 01/2016
2	Attention Deficit and Disruptive Behavior Disorders (Disruptive Behavior Disorder) 01/2021 - 12/2018
2	Antisocial Personality Disorder (Antisocial Personality) 12/2018 - 02/2014
2	Cognitive Dysfunction 10/2017 - 08/2007
2	Marijuana Abuse (Cannabis Abuse) 07/2014 - 03/2012
2	Weight Gain 11/2013 - 04/2012
2	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 04/2013 - 11/2011
2	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2011 - 03/2008
2	Acquired Immunodeficiency Syndrome (AIDS) 08/2005 - 09/2002
1	Hyperthermia 12/2021
1	Dehydration (Water Stress) 12/2021
1	Hyponatremia 12/2021
1	Poisoning 10/2019
1	Liver Diseases (Liver Disease) 01/2018

Drug/Important Bio-Agent (IBA)

25	Pharmaceutical PreparationsIBA 01/2021 - 09/2002
18	Opioid Analgesics (Opioids)IBA 01/2021 - 07/2006
17	Cocaine (Cocaine HCl)IBA 01/2021 - 12/2003
14	Heroin (Diamorphine)IBA 01/2021 - 09/2002
10	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 04/2008
8	Illicit Drugs (Recreational Drugs)IBA 12/2021 - 06/2011
7	Antipsychotic Agents (Antipsychotics)IBA 04/2020 - 07/2014
7	Baclofen FDA LinkGeneric 02/2020 - 12/2016
7	Naltrexone (ReVia)FDA LinkGeneric 07/2015 - 07/2006
6	Methadone (Dolophine)FDA LinkGeneric 05/2016 - 09/2002
5	Methylphenidate (Ritalin)FDA LinkGeneric 01/2021 - 08/2013
5	4-hydroxybutyric acidIBA 01/2020 - 03/2015
5	Nicotine FDA Link 01/2018 - 02/2010
5	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2018 - 04/2008
5	nalmefene (Revex)FDA Link 12/2016 - 04/2013
4	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/2020 - 12/2014
4	Varenicline (Chantix)FDA Link 01/2018 - 09/2009
4	Dronabinol (THC)FDA LinkGeneric 01/2018 - 07/2014
4	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 07/2015 - 12/2013
4	Modafinil (Provigil)FDA Link 06/2015 - 02/2013
4	Acamprosate (Campral)FDA Link 10/2010 - 03/2005
3	SmokeIBA 01/2021 - 07/2014
3	CannabidiolIBA 01/2018 - 03/2015
3	Olanzapine (Zyprexa)FDA Link 01/2017 - 04/2008
3	CannabinoidsIBA 12/2015 - 02/2012
3	Crack CocaineIBA 12/2015 - 08/2011
3	Amphetamine (Amfetamine)FDA LinkGeneric 11/2015 - 07/2012
2	Caffeine (No Doz)FDA LinkGeneric 01/2022 - 07/2012
2	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 11/2021 - 01/2020
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2021 - 05/2004
2	Clozapine (Clozaril)FDA LinkGeneric 01/2018 - 07/2014
2	Glutamic Acid (Glutamate)FDA Link 10/2017 - 01/2011
2	Opiate AlkaloidsIBA 11/2015 - 09/2006
2	Narcotic Antagonists (Opioid Antagonists)IBA 07/2015 - 03/2015
2	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 04/2012 - 04/2008
2	Serotonin (5 Hydroxytryptamine)IBA 04/2012 - 08/2007
2	Buprenorphine (Subutex)FDA LinkGeneric 04/2011 - 11/2006
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2003 - 12/2002
2	Fluvoxamine (Luvox)FDA LinkGeneric 01/2003 - 12/2002
1	Psilocybin (Psilocibin)IBA 06/2022
1	TeaIBA 01/2022
1	Coffee FDA Link 01/2022
1	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 12/2021
1	Therapeutic UsesIBA 12/2021
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 04/2020
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2020
1	AcidsIBA 01/2020
1	Oxycodone (Oxycontin)FDA LinkGeneric 10/2019
1	Dynorphins (Dynorphin)IBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2019
1	preproenkephalinIBA 01/2019
1	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2019
1	Dopamine Agonists (Dopamine Agonist)IBA 12/2018
1	Bupropion (Wellbutrin)FDA LinkGeneric 01/2018

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 08/2021 - 09/2002
5	Self Medication 01/2022 - 02/2014
4	Therapeutics 01/2020 - 09/2005
4	Secondary Prevention 01/2019 - 12/2003
3	Deep Brain Stimulation 04/2013 - 11/2011
1	Induced Hyperthermia (Thermotherapy) 12/2021
1	Pain Management 01/2021
1	Treatment Delay 01/2021
1	Opiate Substitution Treatment 01/2021
1	Surgical Instruments (Clip) 01/2020
1	Transcranial Magnetic Stimulation 01/2019